NLRP3 and myelodysplastic syndrome: Loss of TET2 function increases innate immune signaling by downregulating immune cell proinflammatory cytokines and interferons (16). TET2 mutations in macrophages are linked to increased IL-1β-NLRP3 signaling, contributing to MDS (16). In MDS patients, TET2 mutations suppress NK-cell function (22).