As components of the citric acid cycle, IDH1 and IDH2 help produce energy through the transformation of isocitrate into alpha-ketoglutarate (21). Mutations in IDH1/2 usually result in alpha-ketoglutarate being enzymatically converted to 2-hydroxyglutarate, an oncometabolite, in leukemias (21). Here, IDH2 is linked to leukemia.