The UMAP plot revealed the presence of nine distinct cell populations: B cells, CD4+ conventional T cells (CD4Tconv), exhausted CD8+ T cells (CD8Tex), endothelial cells, fibroblasts, malignant tumor cells, monocytes/macrophages (Mono/Macro), natural killer (NK) cells, and proliferating T cells (Tprolif) (Figure 7D). Here, CD4 is linked to cancer.