Higher frequency of CC and CT genotypes in individuals with ulcerative colitis but it did not affect the development of Crohn’s disease. HLA-C expression on the surface of CD3e+CD8a+ T lymphocyte, neutrophils, and macrophages were higher than TTIndividuals with AA or AG genotypes had higher expression than those with GG genotypes in CD3e+CD8a+ T lymphocyte; however expression was not affected in macrophages and neutrophils. Here, CD8A is linked to Crohn disease.