Variants in the promoter region of HLA-DQA1 were strongly associated with idiopathic membranous nephropathy in the Chinese Han population. Using RegulomeDB rs72848263, rs114929610, rs36173887, rs115222936, and rs28383345 could affect the binding motifs of transcription factors. Rs28383345 is found in the open reading frame of HLA-DQA1 and may affect translation. The gene discussed is HLA-DQA1; the disease is membranous glomerulonephritis.