Melittin, an effective component extracted from bee venom, can directly reduce the activity of microglia or indirectly reduce the secretion of inflammatory factors and the phosphorylation level of P38 mitogen-activated protein kinase in brain stem and spinal cord, significantly regulate the inflammation of ALS mice and delay the development of the disease (35). This evidence concerns the gene MAPK14 and amyotrophic lateral sclerosis.