The synaptic proteins such as post-synaptic density protein 95 (PSD-95), synaptophysin (SYN), and synaptosomal associated protein 23 (SNAP23) are essential for regulating various neurotransmitters and have been found to be modified in neurodegenerative diseases (Bereczki et al., 2018; Hsieh et al., 2006). This evidence concerns the gene SYP and neurodegenerative disease.