One study that compared non-anemic patients with CeD patients with iron deficiency anemia observed that the CeD group had a higher relative Firmicutes abundance (48), and another indicated that Firmicutes bacteria such as CAG 83 and Ruminococcus bicirculans were reduced in patients with positive anti-TG2 IgA serology (50). This evidence concerns the gene TGM2 and cranioectodermal dysplasia.