As witnessed by our computational studies, the remarkable binding affinity of the bioactive compounds of Terminalia elliptica namely Chebulinic acid with VEGF, MTA1 and Chebulagic acid with FAK do hint us of the possible inhibitory potential of this natural molecule to combat tumor proliferation and metastasis targeting VEGF mediated angiogenesis, and FAK regulated and MTA1 associated metastases. This evidence concerns the gene PTK2 and neoplasm.