MELK overexpression has been described in many cancers and cancer stem cells (Rhodes et al., 2004; Nakano et al., 2005; Nakano et al., 2008; Nakano and Kornblum, 2009; Pickard et al., 2009; Hebbard et al., 2010; Kappadakunnel et al., 2010; Kuner et al., 2013; Wang et al., 2014; Settleman et al., 2018). This evidence concerns the gene MELK and cancer.