MAPT and Alzheimer disease: Several factors are known to contribute to the progression of AD, including alterations of the brain cells (De Strooper and Karran, 2016) and vasculature (Sweeney et al., 2018), inflammation (Sweeney et al., 2018), accumulation of amyloid beta and hyperphosphorylated tau (Long and Holtzman, 2019), and genetic predisposition (Gatz et al., 2006; Jansen et al., 2019).