IGF1 and prostate cancer: The presence of insulin-like growth factor I (IGF-1) is considered a risk factor for the development and growth of prostate cancer (28) due to its signaling through RAS/RAF/MAPK (29); however, due to its neurotrophic role, it is essential for normal development and plasticity in the nervous system, which is why it has been the subject of investigation for its possible therapeutic and protective effects on ALS (30).