Compared with individuals without delirium, persistent delirium was associated with elevated glial fibrillary acidic protein (normalized coefficient per transformed standard deviation, β = 0.85; 95% confidence interval: 0.03–1.68) and neurofilament light chain (β = 1.1; 95% confidence interval: 0.5–1.6), but not phosphorylated tau181. The gene discussed is GFAP; the disease is delirium.