Several studies have demonstrated the presence of hyperphosphorylated tau and Aβ in the hippocampus and cortex that correlate with cognitive dysfunction in human epilepsy.15-17,49,77 In contrast, one study reported that tau pathology and Aβ are not as prevalent as reported in the literature and not necessarily correlate with cognitive impairments in epilepsy.78 In the present study, apart from the increased pTau (AT8), we, for the first time, also showed the upregulation of pY18 and Fyn/SFK activation (pSFK) levels accompanied by increased Fyn-tau interactions in human epilepsy. Here, MAPT is linked to epilepsy.