MAPT and nervous system disorder: Tau is an axonal microtubule-associated protein which regulates microtubule stability and axonal transport of micromolecules under physiological condition.12 However, neurological disorders such as seizures can phosphorylate tau and facilitate interactions with other proteins to impair neuronal function.13,14 Seizures induced by the glutamate agonist kainate (KA) cause sustained increase in tau phosphorylation within 24 h,14 suggesting the role of tau pathology in seizure-mediated neurotoxicity.