Many, including our publications, have shown that tau ablation is protective against seizures7-11 and Fyn/SFK inhibition modifies the progression of epilepsy.7,25,27 Our KO mouse study, indeed, revealed that depletion of tau prevented SE-induced hyperexcitability, perhaps by inactivating Fyn and NR2B and thereby reducing the formation of NR2B-PSD95 complexes. The gene discussed is MAPT; the disease is epilepsy.