Tau pathology has been associated with neuronal hyperexcitability and excitotoxicity in epilepsy models,14,46-48 human epilepsy15-17,49-51 and Alzheimer’s disease patients.2 On the other hand, Fyn promotes network excitability6,7,24 and seizure-induced neuroinflammation.27,28 The interactions between the SH3 domain of Fyn and PxxP5/6 motifs of tau contribute to neurotoxicity in Alzheimer’s disease.20,33,34,52-54. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.