In transgenic fyn KO (Tg/fyn−/−) mice where tauopathy mice crossed with fyn KO mice, there was near-complete ablation of neurofibrillary tangles, reduced tau hyperphosphorylation, altered tau solubility and diminished synaptic tau accumulation.57,84 Gene KO approach is not clinically feasible; therefore, we inactivated Fyn/SFK using a pharmacological inhibitor SAR in the rat model, which suppressed seizure-induced postsynaptic activation of NR2B and tau phosphorylation at AT8, but not Y18 and nNOS. The gene discussed is FYN; the disease is tauopathy.