From a genetic point of view, the combination of RPTOR rs11868112, RPS6KA2 rs6456121, and SNCA rs356219 could collectively cause an earlier age at the onset of PD, of which the RPTOR gene expresses Raptor protein, one component of the mTORC1 complex, and the RPS6KA2 gene expresses RSK3 protein, engaged in the activation of the mTOR pathway [46]. This evidence concerns the gene RPS6KA2 and Parkinson disease.