OPRK1 and post-traumatic stress disorder: The clarification of such putative underpinnings to alterations in the affective state in the etiology and ongoing pathophysiology of PTSD should better clarify the effects of the natural products reviewed above, as well as provide novel pharmaceutical and nutriceutical targets, as well as integrate the benefits of current treatments, such as the kappa-opioid receptor antagonist, buprenorphine [111].