A study examining the role of EBV infections in the pathogenesis of SLE in humans found that the IKZF2 was one of the most differentially expressed genes in EBV‐infected B cells compared to normal B cells [62], but little more is known about regulation of Helios expression in B cells or its effects on human B cells. This evidence concerns the gene IKZF2 and systemic lupus erythematosus.