IKZF2 and systemic lupus erythematosus: SLE, a prototypical disease of autoantibody production, or autoimmunity reminiscent to SLE is seen in both fractions of patients with IKZF2 variants and in older Ikzf2−/− mice [30, 41, 42], and polymorphism in Helios have been identified as a risk factor for SLE in humans [60, 61].