CTLA4 and hyperinsulinemic hypoglycemia, familial, 4: Changes in the T cell compartment of the germinal centre, reminiscent of those seen in Helios deficiency, are also seen secondary to other mutations affecting function of TfRs: in mice knockdown of Foxp3 or Ctla‐4 lead to accumulation of both TfH and TfR in the lymph nodes [54, 55].