IFITM3 expression is increased in megakaryocytes and platelets during acute dengue and COVID-19 infections (Campbell et al., 2019; Manne et al., 2020; Zhu et al., 2022a), inhibiting, for instance, DENV entry and replication in megakaryocytes (Campbell et al., 2019). This evidence concerns the gene IFITM3 and dengue disease.