One of the viral restriction factors potentially modulated by viral infection is IFITM3, a factor that functions at the convergence between megakaryocyte differentiation (Campbell et al., 2019) and antiviral responses, including responses against HIV-1 (Lu et al., 2011; Compton et al., 2014, 2016; Shi et al., 2017). This evidence concerns the gene IFITM3 and viral infectious disease.