Although significantly, TNFα transcript increase was very modest after DSS and the effect of ABR167 treatment on TNFα expression was not significant, which could be linked to used DSS model properties with only moderate level of induced colitis due to experimental protocol setup (only 4 days of 2.5% DSS exposure), which we opted in present study to detect even moderate improvement in colitis after ABR167 treatment. This evidence concerns the gene TNF and colitis.