In another study, chlorogenic acid enhanced regorafenib-mediated growth inhibition and apoptosis aggravation in HCC cells, with activation of Annexin V, Bax, and Caspase 3/7 as well as inhibition of Bcl-2 and Bcl-xL, by inhibiting the MAPK and PI3K/Akt/mTORC pathways [272]. The gene discussed is CASP3; the disease is hepatocellular carcinoma.