AKT1 and familial pancreatic carcinoma: Saikosaponin D could also inhibit the invasion of pancreatic cancer cells, modulate the immunosuppressive microenvironment, and reactivate the local immune response, by decreasing the shift toward M2 macrophage polarization via downregulating STAT6 phosphorylation and inhibiting PI3K/Akt/mTOR pathway [267].