Li et al. showed that Rh2 significantly reversed the immunosuppressive pancreatic tumor microenvironment by activating dendritic cells via caspase recruitment domain family member 9-BCL10 immune signaling adaptor-MALT1 paracaspase- nuclear factor kappa B (CARD9-BCL10-MALT1/NF-κB) pathway [185]. Here, CARD9 is linked to pancreatic neoplasm.