Genes associated with primary hip OA across at least two large GWASes (N > 100,000) include IL11, COL11A1, GSDMC, TNC, LTBP3, HFE/HIST1H2BC, LMX1B and NACA2. Pathway analyses linked these OA candidate genes to skeletal development or rare monogenic bone disorders [33]. This evidence concerns the gene TNC and bone disorder.