Our study aimed to determine whether genetic IL-6 polymorphisms, serum interleukin-6 level and inflammatory markers (Presepsin, CXCL-10, C3, C4) are associated in the prediction of disease severity in pediatric COVID-19 patients and its possible use as a prognostic tool in pediatric COVID-19 patients admitted to hospital. This evidence concerns the gene C3 and COVID-19.