Fibroblasts can be broadly categorized into three main types: Normal fibroblasts (FB-CLU-matrix), characterized by the marker CLU, NEAT1, and BASP1, which maintains tissue structural integrity and participates in the wound repair process in normal tissues; and myofibroblasts that are further divided into two subtypes: MyoFB-C1-matrix which is identified by ATAC2, MYH11, TAGLN, PDGFRB, RGS5, and NOTCH3, and MyoFB-C2-activated by ATAC2, MYH11, TAGLN, THY1, PDGFRB, RGS5, and NOTCH3. These factors influence tumor cell migration and invasion. Here, RGS5 is linked to neoplasm.