Our meta-analysis revealed that patients with prediabetes and IGF + IGT have a greater risk of T2D, suggesting that it is more reasonable to classify prediabetes into three subtypes, as ADA does.166 T2D has long been found mostly in adults, but it is increasingly common in adolescents and children due to the increase in obesity in these individuals.167 It is important to note that we set absolute blood glucose cutoff points, but blood glucose abnormalities and the risk of developing T2D are continuous processes. The gene discussed is IGF1; the disease is obesity due to melanocortin 4 receptor deficiency.