NAMPT and diabetes mellitus: Firstly, less adiponectin from adipose tissue reduces the activation of CaMKKβ due to the downregulation of nicotinamide phosphoribosyl transferase (NAMPT),74,95 leading to a weaker AMPK activity, which can be observed long before the onset of diabetes.96 Meanwhile, high glucose and inflammation block LKB1 recruitment, activate PP2A/C, and induce degradation of AMPK catalytic subunits through the E3 ubiquitin ligase.