Interestingly, our results showed a significant induction of lipid oxidation and expression of Ptgs2 in RAW264.7 cells at 0.5 hours after infection when the MOI of GBS and RAW264.7 reached 10:1 or 30:1(Supplementary Fig. 2A, B), elucidating the observation of ferroptosis in peritoneal macrophages despite the inhibition of IL-1β. The gene discussed is PTGS2; the disease is infection.