PROM1 and inborn error of immunity: To assess the impact of PROM1 exon 4 skipping and/or reduced Prominin-1 expression in the ROs we performed bulk RNA-Seq analysis, which revealed an upregulation of several signalling pathways involved in immune response (cytokine and interferon signalling related to primary immunodeficiency response as well as complement activation), cell survival and cell death (p53 signalling pathway, negative regulation of autophagy), metabolism (glycogen metabolism) and protein metabolism (proteostasis).