PROM1 and retinal degeneration: Prom1-knockout mice [43], zebrafish [46] and frog [47] display similar features akin to those obtained in our study including shortened OSs, abolishment of the OS/IS, mis-localization of cone M-opsin, presence of dysmorphic cones, reduction in cone photoreceptors, and retinal degeneration, hence the decrease in Prominin-1 expression could be the underlying factor behind all these observations.