Therefore, our study sought to investigate the potential biological relevance of miR-101 in tumorigenesis, building upon prior research conducted by our group that established miR-101’s ability to suppress malignant characteristics in HCC cells by concurrently targeting oncogenes such as STMN1 (proliferation), JUNB (angiogenesis) and CXCR7 (migration/invasion) [31]. This evidence concerns the gene ACKR3 and hepatocellular carcinoma.