PPP3CB and cancer: PPP3CB encodes the catalytic subunit of calcineurin, a pro-tumorigenic protein whose pharmacological targeting has been reported to have potent antitumor effects in various cancers (Medyouf et al, 2007; Siamakpour-Reihani et al, 2011; Kawahara et al, 2015a, 2015b).