MMP8 and periodontitis: Subsequently, periodontal disease induces the conversion of the inactive latent/pro-forms of total MMP-8 into its active collagenolytic form (aMMP-8), which can be easily detected using aMMP-8 PoC test kits.9, 17, 18, 19, 21, 25Consequently, patients with both severe periodontitis and blood sugar imbalances have abnormally elevated levels of aMMP-8 in their mouthrinse samples.