Among stage III grade C periodontitis patients, aMMP-8 levels were significantly positively correlated with prediabetes (Spearman's rho = 0.646,p = 0.044), total MMP-8 (rho = 0.636,p = 0.048), PMN Elastase (rho = 0.729,p = 0.017), total MMP-9 (rho = 0.721,p = 0.019), and total MMP-8/TIMP-1 molar ratio (rho = 0.879,p < 0.001). The gene discussed is TIMP1; the disease is prediabetes syndrome.