EWSR1 and Ewing sarcoma: Additionally, Ewing’s sarcoma cell lines with the EWS-FLI1 fusion, such as TC-205, CHLA10, and CB-AGPN, demonstrated a higher sensitivity to YJ9069 compared to other sarcoma cell lines, which is in line with a previous report that THZ531 impairs DNA damage repair in an EWS/FLI-dependent manner in Ewing sarcoma.20