In contrast, another proband had two pathogenic variants in genes linked with highly overlapping conditions, and all their phenotypes were potentially attributable to either NF1 (Neurofibromatosis-Noonan syndrome [MIM: 601321]) or CBL (Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia [MIM: 613563]). The gene discussed is NF1; the disease is neurofibromatosis.