Vaccine-induced protection presumably depends on cellular responses to early parasite liver stages, but humoral immunity contributes.<h4>Methods</h4>On custom-made Pf protein microarrays, we profiled IgG and IgM responses to PfSPZ Vaccine and subsequent homologous controlled human malaria infection (CHMI) in 21 Tanzanian adults with (n = 12) or without (n = 9) HIV infection. The gene discussed is CD40LG; the disease is HIV infectious disease.