We show that PfMSP5 is detectable on the surface and in the apical complex of PfSPZ.<h4>Interpretation</h4>Our data demonstrate that HIV infection does not affect the quantity of the total IgG and IgM antibody responses to PfCSP and PfMSP5 after immunization with PfSPZ Vaccine. This evidence concerns the gene CD40LG and HIV infectious disease.