The idea of LPS-induced cholestasis is not novel,34,35 but is underappreciated during cancer therapy where intestinal barrier function is routinely disrupted,43 promoting systemic LPS exposure that can induce cholestasis.44 Chemo mice exhibited indicators of intestinal barrier disruption and hepatic endotoxemia, including elevated hepatic LBP and reduced intestinal crypt depth and villus height. This evidence concerns the gene LBP and cholestasis.