Previous studies [31–34] have generated compelling results indicating that the latency-associated transcript (LAT) of HSV-1 modulates the effects of type I IFN induction in the trigeminal ganglia (TG) of wild-type (WT) mice after ocular infection with LAT(+) virus as compared with LAT(-) virus, which suggests that LAT acts to suppress the production of IFNα. This evidence concerns the gene LAT and eye infection.