As expected, cGAS-, STING-, and Ifi204-deficient mice each demonstrated increased baseline susceptibility to influenza challenges, but the magnitude of Pam2ODN-induced protection against viral or bacterial challenges was unaffected in knockout mice (Supplemental Figure 1), effectively excluding cGAS-STING or Ifi204 as critical to Pam2ODN-inducible resistance. Here, CGAS is linked to influenza.