Moreover, EC-specific YAP overexpression or expression of constitutively active YAP/TAZ mutants aggravates atherosclerosis in Apoe–/– mice, and YAP/TAZ activation in cultured human ECs triggers inflammation and increases the expression of adhesion molecules and leukocyte-interacting receptors (20, 21, 30). Here, YAP1 is linked to atherosclerosis.