In normal cells, alternative splicing of LMNA transcripts results in 2 main protein variants, lamin A and lamin C. Most HGPS patients carry the synonymous c.1824C>T (p.Gly608Gly) LMNA mutation, which creates an aberrant splicing site in exon 11, resulting in deletion of 150 nucleotides and the synthesis of a truncated variant of lamin A called progerin. This evidence concerns the gene LMNA and Hutchinson-Gilford progeria syndrome.