To reveal the pathogenic mechanism of NS in patients with heterozygous LZTR1 AD mutations, we generated 2 types of Lztr1–knock-in mice harboring the p.R409C and p.G245R mutations, which are inherited human AD mutations corresponding to p.R412C and p.G248R, respectively (Figure 1A and Supplemental Figure 1; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.182382DS1) (4, 14, 15, 17, 21, 32). The gene discussed is LZTR1; the disease is Alzheimer disease.