By analyzing the RNA-seq data as well as microarray data of SF763 cells with PTEN-KO versus WT (20), we identified 4 genes (OLFML3, LOXL1, ADAMTS9, and TGFA) that were upregulated by LOX knockdown and downregulated by PTEN KO in GBM cells (Figure 3, A and B). The gene discussed is ADAMTS9; the disease is glioblastoma.