CASP1 and psoriasis: In line with our data, another study shows that EFLA 945, a constituent of red grape vine leaf extracts known to prevent DNA entry, attenuates IMQ-induced psoriasis–related proinflammatory responses in topical psoriatic skin, including caspase-1 activation, IL-1β maturation, and IL-17 production, and decreases the severity of psoriasis.