CD4 and respiratory system disorder: Previous studies on alum adjuvanted RSV vaccines and few preclinical SARS‐CoV research have shown that vaccine‐associated enhanced respiratory disease (VAERD), has a connection with CD4 TH2‐type response.[63, 64] However, our results showed that the RIG‐I targeted PUUC+CpG and PUUC PAL‐NP group induces TRM in the lungs, which expresses TH1‐type cytokines with suppressed or very low detection levels of TH2‐type cytokines.