Specifically, in the high-risk cohort, key immune-related functional indicators—including cytolytic activity, human leukocyte antigen (HLA), T cell co-stimulation, type II interferon (IFN) response, T cell co-inhibition, chemokine receptor (CCR), tumor-infiltrating lymphocytes (TILs), and CD8 + T cells—demonstrated diminished activity. This evidence concerns the gene IFNA1 and neoplasm.