In the existing research, OGFRP1 was investigated to enhance the growth of gastric cancer cells and inhibit cell death and sensitivity to radiation by controlling the miR-149-5p/MAP3K3 pathway [27], which has been demonstrated to play a similar role in choriocarcinoma through the miR-4731-5p/HIF3A axis [28]. Here, MAP3K3 is linked to choriocarcinoma.