The finding that dysplastic cells in COVID-19 patient lungs express p-SRC and nuclear YAP signal and that IFN-γ promotes human AT2 cell transdifferentiate into dysplastic cells in a FAK/Src-dependent manner suggests that IFN-γ–mediated activation of the FAK/Src-YAP signaling axis may also regulate dysplastic alveolar remodeling in viral-infected human lungs. The gene discussed is IFNG; the disease is COVID-19.