We found 4 genes with recurrent mutations before ARSI (AKT1, AR, CDK12, and SPATA31E1); the former 3 are known to mutate in PCa, and their mutations in our dataset are known to be pathogenic (AKT1 E17K and AR T878A) or consistent with the known mechanisms of pathogenicity (the CDK12 stop gain mutation causing loss of function). The gene discussed is ARSI; the disease is posterior cortical atrophy.