We found 4 genes with recurrent mutations before ARSI (AKT1, AR, CDK12, and SPATA31E1); the former 3 are known to mutate in PCa, and their mutations in our dataset are known to be pathogenic (AKT1 E17K and AR T878A) or consistent with the known mechanisms of pathogenicity (the CDK12 stop gain mutation causing loss of function). This evidence concerns the gene SPATA31E1 and posterior cortical atrophy.