Inspired by the recent progress in understanding mCRPC heterogeneity using advanced sequencing technologies such as ATAC-Seq, we similarly calculated phenotypic scores for each tumor using the key TFs defining the 4 molecular subtypes of mCRPC reported by Tang et al. (17): AR-dependent (CRPC-AR), NE (CRPC-NEPC), Wnt-dependent (CRPC-Wnt), and stem cell-like (CRPC-SCL). This evidence concerns the gene AR and neoplasm.