Atherosclerosis-prone mice transplanted with Trp53–/– hematopoietic cells showed an approximately 40% increase in aortic plaque size relative to Trp53+/+ mice as well as accumulation of intraplaque macrophages, with no effect on proinflammatory cytokines or the NLRP3 inflammasome (27). This evidence concerns the gene NLRP3 and atherosclerosis.