The immunogenic cell death (ICD) after ferroptosis promotes interferon γ (IFN‐γ) secretion to up‐regulate the expression of long‐chain family member 4 (ACSL4), cooperating with the released AA from CTFAP to accelerate the accumulation of lipid peroxidation (LPO) and thereby promoting ferroptosis in cancer cells.CTFAP with ultrasound treatment efficiently suppresses tumor growth, has great potential to challenges in cancer immunotherapy. This evidence concerns the gene ACSL4 and cancer.