These negative regulatory mechanisms of NLRP12 are detrimental to the host during certain infections, for example with S. Typhimurium exploiting NLRP12‐mediated inhibition of NF‐κB and ERK activation and anti‐microbial cytokine production,141 resulting in enhanced pathogen survival and persistence in the host tissue.141, 142, 143. Here, NLRP12 is linked to infection.