Alzheimer's disease (AD) neuropathologic change (ADNC), defined by parenchymal deposits of amyloid beta (Aβ) peptide (“plaques”) and intraneuronal aggregates of hyperphosphorylated tau protein (“neurofibrillary tangles”), is the leading cause of dementia late in life but is not the only cause. Here, MAPT is linked to Alzheimer disease.