MPC1 and familial dilated cardiomyopathy: Unlike HFrEF, SLC2A1 (solute carrier family 2 member 1) gene, which encodes GLUT1 was lower, but mitochondria pyruvate carriers, MPC1 was up-regulated in HFpEF patients.23 However, both MPC1 and MPC2 were down-regulated in end-stage advanced HFrEF patients with DCM.24 These data suggest suppressed mitochondrial pyruvate oxidation in HFrEF but not in HFpEF.