Reduced HF hospitalisation and mortality.169Improved diastolic function.175Reduced left ventricular mass and NT-proBNP level, improved left ventricular function.177–181Increased circulating ketone bodies.182,185Up-regulated sirtuins and promoted autophagy.189Activated AMPK and promoted energy restoration.185Suppressed mTOR hence reduced cellular biogenesis and conserved energy.191. This evidence concerns the gene MTOR and hydrops fetalis.