SREBF1 and metabolic dysfunction-associated steatohepatitis: Hepatic mRNA expression of FASN, the enzyme for de novo lipogenesis, and its transcription factor [sterol regulatory element-binding protein-1c (SREBP-1c)], has been reported to be upregulated in MASLD, but not in metabolic dysfunction-associated steatohepatitis (MASH) in murine models (31, 32).