Furthermore, the reduction of FT3/FT4 ratiowas associated with lower BMI, diastolic blood pressure, estimated glomerular filtration rate (eGFR), left ventricular ejection fraction (LVEF), but higher high sensitivity to C-reactive proteins (Hs-CRP), brain natriuretic peptide (BNP) and prevalence of prior stroke, and was more likely to be diagnosed with STEMI (all P <0.05). The gene discussed is NPPB; the disease is stroke disorder.