A study to demonstrate the safety of a CGM-informed insulin bolus calculator that applies trend arrow and exercise adjustments to bolus insulin dose recommendations and provides real-time coaching found that use of the CGM-informed insulin bolus calculator by individuals with diabetes was associated with significant improvement in time-in-range (TIR; 70-180 mg/dL) without an increase in hypoglycemia or diabetes distress (16). The gene discussed is INS; the disease is Hypoglycemia.