Moreover, our research showed that BHLHE40 amplifies the inflammatory response in the pathogenesis of obesity by instigating the adaptive immune response of Treg cells and CD4+ T cells and promoting the chemotaxis of vital immune molecules, such as CCR, CXCL, and TNFRSF, in tissues. The gene discussed is CD4; the disease is obesity due to melanocortin 4 receptor deficiency.